Identifiers
v-myc myelocytomatosis viral oncogene homolog
HUGO:MYC, HGNC:7553, ENTREZ:4609, GENECARDS:GC08P128748
v-myc myelocytomatosis viral oncogene homolog (avian)
HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106
HUGO:MYC
"v-myc avian myelocytomatosis viral oncogene homolog"
HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / METABOLIC
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_CANONICAL
Survival / WNT_NON_CANONICAL
References
PMID:25002027
We found significantly reduced levels of c-Myc in p62 KO fibroblasts as well as in WT fibroblasts in which p62 has been knocked down by shRNA
PMID:22067385
c-MYC expression is assosiated with M2 type of macrophages.
IL4 induces MYC expression in macrophages. MYC directly regulates some genes associated with alternative activation, including SCARB1, ALOX15, and MRC1, whereas others, including CD209, are indirectly regulated by c-MYC. c-MYC up-regulates the IL-4 signaling mediators signal transducer and activator of transcription-6 and peroxisome proliferator-activated receptor??, is also expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20581311
STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion.
STAT3 directly controls G-CSF-dependent expression of CCAAT-enhancer-binding protein ?? (C/EBP??), a crucial factor in the emergency granulopoiesis response. Moreover, STAT3 and C/EBP?? coregulate c-Myc through interactions with the c-myc promoter that control the duration of C/EBP?? occupancy during demand-driven granulopoiesis.
PMID:11340171
MYC inhibits myeloid cells differentiation.
PMID:16597464
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were signi???cantly increased in macrophages
extracted form WT mice (black columns) following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,
as well as from IRF-1 null mice.
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )