Identifiers
HUGO:CD40
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / ACTIVATING_CHECKPOINTS
Innate Immunity / MARKERS_DC
References
PMID:15197224, PMID:7523569, PMID:9359474
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation.
PMID:11964292, PMID:14764699
IFNAR signaling upregulates surface expression of CD80, CD86, CD40.Probably via STAT1
PMID:8760829
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
PMID:??15034038
IL3 induces CD80, CD86, CD40 surface expression in pDC
PMID:??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c, (PMID:11964292, PMID:11698286, PMID:??11207245)
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II?? )
PMID:17317815
Engagement of CD40 by multimeric CD40L causes redistribution of CD40 to membrane lipid rafts and a conformational change that recruits adapter molecules known as TNF receptor (TNFR)???associated factors (TRAF) to at least two distinct binding sites on the CD40 cytoplasmic tail (67, 68). TRAFs then recruit TRAF-interacting kinases and together influence a number of well-characterized signal transduction pathways, including the nuclear factor-??B, p38/mitogen-activated protein kinase (MAPK), and c-Jun-NH2-kinase (JNK) pathways
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,