Identifiers
HUGO:TNFSF4
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Cancer Associated Fibroblasts / TREG_MODULATORS
References
PMID:27298374
Fibroblast could express OX40L
PMID:17641007
OX40L prevents Treg transformation of naive T cells by inhibition of Foxp3 expression
"we established a two-step T cell culture system with IEk+??fibroblast APC expressing only OX40L. Naive T cells were cultured as before with low-dose Ag for 18 h. These activated cells were then repurified for secondary culture with OX40L-expressing APC in the presence or absence of TGF-??. At 18 h before restimulation, wild-type and OX40???/?????T cells expressed equivalent CD25 and TGF-??RII and no Foxp3 (Fig. 4???A). After restimulation with Ag and OX40L, wild-type T cells did not develop into Foxp3+??cells without the addition of TGF-?? (Fig. 4???,??B??and??C). Moreover, even when TGF-?? was added only a small fraction of T cells became Foxp3+, implying that OX40L specifically suppressed the induction of Foxp3".??
DENDRITIC_CELL
NEUTROPHIL
CASCADE:IL3
CASCADE:CD40LG
PMID:9378971, PMID:10626891
OX40L is expressed on DCs surface after CD40 stimulation.
Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production.
PMID:??17200410, PMID:23125331, PMID:15034038
pDCs stimulated with IL-3 plus CD40L induce production ICOS-L and expression of OX40L.
PMID:24778133
Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL .
PMID:25384214
TANs enhance T cell proliferation by direct cell-cell signaling, likely due to the OX40L/OX40 and 4-1BBL/4-1BB pathways.
→ OX40L*@INNATE_IMMUNE_CELL_Membrane
→ Immune_checkpoints_T_cells_Activators@default