Protein IL3 map

Identifiers
HUGO:IL3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
 DENDRITIC_CELL  map
CASCADE:IL3
PMID:15549123
IL3 signaling is important for plasmacytoid DC which are expressing IL3RA.
PMID:23762788
Tumor-infiltrating plasmacytoid dendritic cells (pDCs) have been associated with poor patient prognosis.??
PMID:??17200410, PMID:23125331, PMID:15034038
pDCs stimulated with IL-3 plus CD40L induce expression ICOS-L and OX40L.
PMID:24778133, PMID:23026134
Expression ot ICOS-L and OX40L ligands by pDC promotes tumor progression by Promoting Th2 and Regulatory Immunity.

Modifications:
In compartment: default
  1. IL3@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CSF2RB:​IL3:​IL3RA@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF2RB:​IL3:​IL3RA@INNATE_IMMUNE_CELL_Membrane map → map IMMUNE_SUPRESSION@default map
  2. IL3@default map + CSF2RB:​IL3RA@INNATE_IMMUNE_CELL_Membrane map → map CSF2RB:​IL3:​IL3RA@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. B7H2*@INNATE_IMMUNE_CELL_Cytosol map → map B7H2*@INNATE_IMMUNE_CELL_Membrane map
  2. CD40@INNATE_IMMUNE_CELL_Cytosol map → map CD40@INNATE_IMMUNE_CELL_Membrane map
  3. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  4. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
  5. OX40L*@INNATE_IMMUNE_CELL_Cytosol map → map OX40L*@INNATE_IMMUNE_CELL_Membrane map