Protein KIR2DS4 map

References
 NATURAL_KILLER  map
CASCADE:KIR2DS4
PMID:11390475, PMID:15265913
KIR2DS4 interacts with HLA-Cw4, but not with HLA-Cw6.
Additionally it is involeved in MHC class I-independent recognition of target cells.
KIR2DS4 signaling is involved in the killing of melanoma cells
PMID:9521070
KIR2DS4 (NKAT8) signaling induces significant intracellular calcium mobilization,
and phosphorylation of the MAP kinases ERK1 and ERK2.Recognition of HLA-Cw3 on target cells
by NKAT8 resulted in enhanced cytotoxicity.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK 5directly demonstrated for KIR2DL3 only.
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIR2DS4@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-C:​KIR2DS4@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HLA-C@TUMOR_CELL_AS_INDUCTOR_Membrane map + KIR2DS4@INNATE_IMMUNE_CELL_Membrane map → map HLA-C:​KIR2DS4@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map