Complex TICAM1:TLR4 map
Complex composition:

  1. TLR4 map
  2. TICAM1 map

TICAM1:​TLR4@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:TICAM1:TLR4

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:TLR2_4
PMID:20154735 , PMID:16306937
TICAM1 (TRIF)/TRAF pathway downstream of TLR4 is MYD88 independent.
PMID:17114424
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
PMID:23508573, PMID:20547845, PMID:15644117
HMGB1 induces secretion of TNFa via TLR4/MyD88 and TRIF (TICAM1) dependent pathway probably via NFkB

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TICAM1:​TLR4@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TLR4@INNATE_IMMUNE_CELL_Membrane map + TICAM1@INNATE_IMMUNE_CELL_Membrane map → map TICAM1:​TLR4@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. TRAF3@INNATE_IMMUNE_CELL_Cytosol map → map TRAF3@INNATE_IMMUNE_CELL_Cytosol map