Protein KIR2DL3 map

Identifiers
HUGO:KIR2DL3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MARKERS_NK  map

References
CASCADE:KIR2DL3
 NATURAL_KILLER  map
PMID:11513144, PMID:8574854
KIRs constitute a family of slightly polymorphic receptors with distinct MHC-I-binding profiles for classical HLA-A, HLA-B, and HLA-C molecules. Most KIRs with two Ig domains (KIR2DL) recognize subsets of the HLA-C allotypes.
KIR2DL3 inhibits NK cells downstream of HLA-C via SHP-1 binding and activation.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK 5directly demonstrated for KIR2DL3 only.
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIR2DL3@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_NK
  1. KIR2DL3@MARKERS_NK map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-C:​KIR2DL3|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HLA-C@TUMOR_CELL_AS_INDUCTOR_Membrane map + KIR2DL3@INNATE_IMMUNE_CELL_Membrane map → map HLA-C:​KIR2DL3|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  2. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map