Identifiers
HUGO:KIR3DL1
References
KIR3DL1
NATURAL_KILLER
PMID:11513144, PMID:8976179, PMID:8986721
KIR3DL1 is a receptor for HLA-B.
Recognition of Inhibitory HLA-B Allotypes (Bw4+) by the KIR NKB1 Alters Stimulatory Signal Transduction Pathways in NK Cells via inhibition of PI3K pathway and Ca2+ mobilization.
Probably it acts via LAT inhibition.KIR recognition of inhibitory class I molecules disrupted the ability of pp36 (LAT) to associate with Grb2 in vitro.
PTP-1C (SHP-1) activated by KIR3DL1 binds to and dephosphorylates pp36 (LAT) and disrupted the ability of pp36 (LAT) to associate with Grb2.
PMID:11994457
Tyrosine-phosphorylated KIR3DL1 inhibits NK cytotoxixity. It inhibits the immunoreceptor tyrosine-based activation motif (ITAM)-dependent activation mediated by NKp46 or the ITAM-independent activation mediated by 2B4.
via binding and activation of SHP-2, SHP-1.3DL1-mediated inhibition of cytotoxicity was abolished upon overexpression of SHP-1.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK 5directly demonstrated for KIR2DL3 only.
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4)
PMID:9605119
Ligation of the NK cell receptor KIR3DL1 by HLA-Bw4 allotypes resulted in inhibition of cytotoxicity against HLA-B*4403-transfected melanomas as well as against melanomas endogenously expressing HLA-Bw4 allotypes.