Protein FGR map

Identifiers
HUGO:FGR

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / FC_RECEPTORS  map

References
 NEUTROPHIL  map
CASCADE:Fc_gamma_RII
PMID:21910624
The ITAM can be part of the same polypeptidic chain that engages the ligand, as in the case of Fc??RIIA and Fc??RIIC, or of a separate ?? subunit that associates noncovalently with the ligand-binding subunit of the receptor, as in the case of Fc??RI and Fc??RIIIA. Upon receptor clustering, the ITAM associates with and becomes phosphorylated by Hck, Lyn (33, 34), and/or Fgr (35).
PMID:8327512
In neutrophiles Fgr is physically and functionally associated with Fc gamma RII and involved in Fc gamma RII-mediated signal transduction pathways.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FGR@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGR@INNATE_IMMUNE_CELL_Cytosol map → map FGR@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map