Protein cleaved Caspase1* map

References
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
CASCADE:P2RX7
CASCADE:TLR2_4
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3). After 2 hours of incubation, monocytes display clear activation of caspase-1 regardless of LPS stimulation.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL1B@INNATE_IMMUNE_CELL_Cytosol map → map trILB1@INNATE_IMMUNE_CELL_Cytosol map