Simple molecule NO map
NO@default

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
 NATURAL_KILLER  map
PMID:22006996, PMID:18559521
Nitric oxide inhibits the hypoxia-induced expression of ADAM10 and the hypoxia-induced accumulation of HIF1A
and decrease MIC shedding.
NO attenuates in vivo tumor growth by sensitizing tumor cells to recognition and elimination by the innate immune system.

NO@INNATE_IMMUNE_CELL_Cytosol

References
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression in rodent macrophage
PMID:24092389
TANs from early tumors are more cytotoxic toward tumor cells and produce higher levels of TNF-??, NO, and H2O2 and, in established tumors, these functions are downregulated and TAN acquire a more protumorigenic phenotype

NO@TUMOR_CELL_AS_INDUCTOR

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
 NATURAL_KILLER  map
PMID:22006996, PMID:18559521
Nitric oxide inhibits the hypoxia-induced expression of ADAM10 and the hypoxia-induced accumulation of HIF1A
and decrease MIC shedding.
NO attenuates in vivo tumor growth by sensitizing tumor cells to recognition and elimination by the innate immune system.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NO@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. NO@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. NO@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. NO@default map → map NO_production@default map
    2. L-arginine@INNATE_IMMUNE_CELL_Cytosol map + O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map + NADPH@INNATE_IMMUNE_CELL_Cytosol map → map NO@INNATE_IMMUNE_CELL_Cytosol map + L-citrulin@INNATE_IMMUNE_CELL_Cytosol map + NADP+@INNATE_IMMUNE_CELL_Cytosol map
    3. NO@INNATE_IMMUNE_CELL_Cytosol map → map NO@default map
    As Catalyser:
    1. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map HIF1A@TUMOR_CELL_AS_INDUCTOR map
    2. gADAM10@TUMOR_CELL_AS_INDUCTOR map → map rADAM10@TUMOR_CELL_AS_INDUCTOR map