Protein NOS2 map

Identifiers
nitric oxide synthase 2, inducible
HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228
HUGO:NOS2

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

References
PMID:17476345
NOS2, a heme-containing enzyme
that catalyzes the synthesis of NO and citrulline from l???Arg, is
expressed by various cells of the immune system, and its activa-
tion is considered a hallmark of classically activated macrophages
(also known as M1 macrophages), a macrophage subset that pro-
duces proinflammatory cytokines and acts as the effector cell in
the killing of invading pathogens and tumor cells.
PMID:11875494
HMOX1 (HO1) mediates the inhibitory effect of IL10
on LPS-induced NOS2 (INOS) expression.
PMID:6357187
Macrophage tumoricidal activity is attributed to NOS2 (iNOS) production.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID:21680779, PMID:22816309
Myeloid-derived suppressor cell inhibit the IFN response in immune cells (splenocytes, macrophages) via inhibition of STAT1 phosphorylation by NO (downstream of iNOS)..

NOS2@INNATE_IMMUNE_CELL_Cytosol

References
in_re484( Innate Immunity  map ):
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NOS2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rNOS2@INNATE_IMMUNE_CELL_Cytosol map → map NOS2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. L-arginine@INNATE_IMMUNE_CELL_Cytosol map + O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map + NADPH@INNATE_IMMUNE_CELL_Cytosol map → map NO@INNATE_IMMUNE_CELL_Cytosol map + L-citrulin@INNATE_IMMUNE_CELL_Cytosol map + NADP+@INNATE_IMMUNE_CELL_Cytosol map