Identifiers
ECSIT homolog (Drosophila)
HUGO:ECSIT HGNC:29548 ENTREZ:51295 UNIPROT:Q9BQ95
HUGO:ECSIT
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
MACROPHAGE
CASCADE:TLR2_4
PMID:25371197,
TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-??B
ECSIT-knockdown monocytic cells exhibited severe impairments in NF-??B activity, cytokine production, and NF-??B-dependent gene expression, whereas those were dramatically restored by reintroduction of wild type (WT) ECSIT gene.
IRF7, IL-1??, CD44, NF-??B2, IER3, IL-8, NF-??B1A, and RelB were markedly decreased in the ECSITKD
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-??B
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.