Protein S100A9 map

Identifiers
HUGO:S100A9

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
 MDSC  map
CASCADE:S100A
PMID:18802069, PMID:23248262
S100A8/A9 proteins are chemotactic for MDSC.
S100A8/A9 proteins bind to carboxylated N-glycans expressed on the receptor (probably RAGE) for advanced glycation end-products and other cell surface glycoprotein receptors on MDSC, signal through the NF-kappaB pathway, and promote MDSC migration and immunosuppressive function in tumor.
PMID:18809714, PMID:12645005
S100A9 regulates myeloid cell differentiation via reactive oxygen species (ROS), probabli via NAPDH oxidase.
S100A9 may suppress myeloid cell differentiation via persistent up-regulation of ROS in progenitor cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. S100A9@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. S100A8:​S100A9@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. RAGE*:​S100A8:​S100A9@INNATE_IMMUNE_CELL_Membrane map
In compartment: default
  1. S100A8:​S100A9@default map
Participates in reactions:
As Reactant or Product:
  1. S100A9@INNATE_IMMUNE_CELL_Cytosol map + S100A8@INNATE_IMMUNE_CELL_Cytosol map → map S100A8:​S100A9@INNATE_IMMUNE_CELL_Cytosol map
  2. S100A8:​S100A9@INNATE_IMMUNE_CELL_Cytosol map → map S100A8:​S100A9@default map
  3. RAGE*:​S100A8:​S100A9@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  4. RAGE*@INNATE_IMMUNE_CELL_Membrane map + S100A8:​S100A9@default map → map RAGE*:​S100A8:​S100A9@INNATE_IMMUNE_CELL_Membrane map
  5. rS100A9@INNATE_IMMUNE_CELL_Cytosol map → map S100A9@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map