Identifiers
ETS proto-oncogene 1, transcription factor
HUGO:ETS1 hgnc_id:HGNC:3488 HGNC:3488 ENTREZ:2113 UNIPROT:P14921
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
HUGO:ETS1, HGNC:3488, ENTREZ:2113, UNIPROT:P14921, GENECARDS:GC11M128328
HUGO:ETS1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Cancer Associated Fibroblasts / FIBROBLAST_ACTIVATION_MARKERS
EMT Senescence / EMT_REGULATORS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / MIRNA_TF_IMMUNOSTIMULATORY
References
CASCADE:TGFB
PMID:15001984
Tenascin-C upregulation by transforming growth factor-?? in human dermal fibroblasts involves Smad3, Sp1, and Ets1
Smad3 complex interact with SP1 and ETS1 and induces activity of TN-C promoter.
PMID:16391805
Ets-1 is a transcription factor
Ets-1 involves in inducing MMP2 expression by EMT in human squamous carcinoma cells
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
The Ets gene family conserves an 85-amino acid DNA-binding ETS domain that binds the consensus sequence 5'-GGA(A/T)-3' in the promoter region of the target genes.
Ets has various biological functions, including cellular growth, differentiation, and organ development.
Ets-1, first identified among the Ets gene family, has been shown to also be associated with pathological angiogenesis.
A number of angiogenesis-related molecules, including MMP-1, MMP-3, MMP-9, integrin 3, vascular endothelial cadherin (VE-cadherin), and neuropilin-1 (NRP1) are reported to be targets of Ets-1 in endothelial cells
PMID:21081489
Endogenous Ets-1 is a key mediator of cell migration and Matrigel tube formation in HMECs (human microvascular endothelial cells)
PMID:21041997
In cells induced to undergo EMT, TGFB also activates the expresion of ZEB1 and ZEB2 through upregulation of ETS1 expression, which then may cooperate with the bHLH transcription factor E47 (TCF3)
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)
NATURAL_KILLER
CASCADE:IL15
CASCADE:IL2
PMID:22608498
ETS1 binds directly to the Tbx21 and IL2RB (CD122) genes and induces its expression in NK cells.
expression of Ncr1 (NKp46), Cd122 (il2RB), Idb2, Ltb, Lair1 and Tbx21 mRNA is reduced in NK cells after knockdown of ETS1.