Protein KLF4 map

Identifiers
HUGO:KLF4
Kruppel-like factor 4 (gut)
HUGO:KLF4 HGNC:6348 ENTREZ:9314 UNIPROT:O43474 GENECARDS:KLF4 REACTOME:58119 KEGG:9314 ATLASONC:KLF4ID44316ch9q31 WIKI:KLF4

Maps_Modules
HMC:ENABLING_REPLICATION_AND_IMMORTALITY
 Telomere Maintenance  map  / TELOMERASE  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:21670502
KLF4 together with STAT6 upregulates expression of PPARG and ARG1 downstream of IL4.
KLF4-deficient macrophages demonstrated increased proinflammatory gene expression, enhanced bactericidal activity, and altered metabolism.
KLF4 inhibits PTGS2 (COX2) expression. Probably via prevention of NFkB activaiton.

KLF4@INNATE_IMMUNE_CELL_Cytosol

References
in_re471( Innate Immunity  map ):
PMID:12193690
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
PMID:10925299, PMID:6357187
IL-13 induces de novo synthesis of arginase I mRNA and protein. Probably via STAT6.
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.
in_re1107( Innate Immunity  map ):
PMID:10432118, PMID:21093321
IL4 upregulates expression of PPARG via JAK3/STAT6 pathway

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. KLF4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rKLF4@INNATE_IMMUNE_CELL_Cytosol map → map KLF4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gPPARG@INNATE_IMMUNE_CELL_Cytosol map → map rPPARG@INNATE_IMMUNE_CELL_Cytosol map
    2. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
    3. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map