Protein MNK1 map

Identifiers
HUGO:MKNK1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:IL10
CASCADE:IL15
CASCADE:IL2
PMID:15563472
Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
Phosphorylation by MNK1 serves to activate eIF4E.eIF4E induces translation of ETS1by recruiting mRNAs to the ribosome,
and upregulates ETS1 protein level.
PMID:22955274
SHIP inhibit MAPKp38 activation and prevent MNK1 phosphorylation by inhibiting the p38 MAPK pathway downstream of IL10. MNK1 regulates TNFa mRNA polysome assembly and upregulates TNFa translation.IL-10 Inhibits TNF Translation through SHIP1-mediated Inhibition of Mnk1

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MNK1@INNATE_IMMUNE_CELL_Cytosol map
  2. MNK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MNK1@INNATE_IMMUNE_CELL_Cytosol map → map MNK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. rTNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@INNATE_IMMUNE_CELL_Cytosol map
    2. gETS1@INNATE_IMMUNE_CELL_Cytosol map → map rETS1@INNATE_IMMUNE_CELL_Cytosol map
    3. EIF4E@INNATE_IMMUNE_CELL_Cytosol map → map EIF4E|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map