Protein EIF4E map

Identifiers
HUGO:EIF4E
eukaryotic translation initiation factor 4E
HUGO:EIF4E, HGNC:3287, ENTREZ:1977, GENECARDS:GC04M099799, UNIPROT:P06730
HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:9878069
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
PMID:9155017
In vitro, Mnk1 rapidly phosphorylates eIF-4E at the physiologically relevant site, Ser209
Phosphorylation of eIF-4E is believed to enhance its affinity for the 5'-cap
 NATURAL_KILLER  map
PMID:15563472
Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
Phosphorylation by MNK1 serves to activate eIF4E.eIF4E induces translation of ETS1by recruiting mRNAs to the ribosome,
and upregulates ETS1 protein level.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. EIF4E@INNATE_IMMUNE_CELL_Cytosol map
  2. EIF4E|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. EIF4E@INNATE_IMMUNE_CELL_Cytosol map → map EIF4E|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. rETS1@INNATE_IMMUNE_CELL_Cytosol map → map ETS1@INNATE_IMMUNE_CELL_Cytosol map