Protein CALR map

Identifiers
calreticulin
HUGO:CALR hgnc_id:HGNC:1455 HGNC:1455 ENTREZ:811 UNIPROT:P27797
HUGO:CALR

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
PMID:23850759
 DENDRITIC_CELL  map
 MACROPHAGE  map
 NEUTROPHIL  map
CASCADE:LRP1
PMID:16181333, PMID:22076556
CALR (CRT or calreticulin) is a lectin specific for monoglucosylated N-linked glycans (17) that binds to the MHC class I molecule via its carbohydrate side chain. It also associates non-covalently with ERp57 in peptide-loading complex.
PMID:17204652
DCs, which are biased for MHCI cross-presentation, were enriched in Tap1, Tap2, calreticulin, calnexin, Sec61, ERp57, ERAAP, as well as cystatin B and C, all of which are involved in MHCI presentation or inhibition of enzymes that process peptides
PMID:14508489
Together with TAP, tapasin, calreticulin, ERp57 and the heavy chain of MHC class I were all detected in purified early phagosomes by western blotting
PMID:23157435, PMID:16239148, PMID:20958319
CALR (CRT or calreticulin) is released by dying tumor cells and acts as eat-me signal. It acts via CD91 (LRP1) and initiates clearance of viable or apoptotic cells.

Modifications:
In compartment: default
  1. CALR@default map
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane
  1. CALR:​PDIA3@Endoplasmic Reticulum_Membrane map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CALR:​LRP1@INNATE_IMMUNE_CELL_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CALR:​PDIA3@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CALR@default map + LRP1@INNATE_IMMUNE_CELL_Membrane map → map CALR:​LRP1@INNATE_IMMUNE_CELL_Membrane map
  2. CALR:​LRP1@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  3. EAT_ME@TUMOR_CELL_AS_INDUCTOR map → map CALR@default map
As Catalyser:
  1. B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map + Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map
  2. B2M:​MHC_class_I*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map