Identifiers
NAME:TAP1:TAP2:TAPASIN*
References
DENDRITIC_CELL
in_re12( Innate Immunity ):
PMID:22790179
The SNARE SEC22B, which localizes in the ER???Golgi intermediate compartment (ERGIC) and interacts with syntaxin 4 on phagosomes, mediates the recruitment of a subset of ER components, including transporter associated with antigen processing (TAP), to phagosomes.
in_re13( Innate Immunity ):
PMID:22790179, PMID:14508489
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways.
After antigen export to the cytosol and degradation by the proteasome, peptides are translocated by TAP into the lumen of the same phagosomes, before loading on phagosomal MHC class I molecules.
Identifiers
NAME:TAP1:TAP2:TAPASIN*
References
DENDRITIC_CELL
in_re5( Innate Immunity ):
PMID:22790179, PMID:14508489
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways.
After phagocytosis, antigens are exported into the cytosol and degraded by the proteasome4, 5, 6. The resulting peptides are thought to be translocated into the lumen of the endoplasmic reticulum (ER) by specific transporters associated with antigen presentation (TAP), and loaded onto MHC class I molecules by a complex ???loading machinery??? (which includes tapasin, calreticulin and Erp57)
in_re12( Innate Immunity ):
PMID:22790179
The SNARE SEC22B, which localizes in the ER???Golgi intermediate compartment (ERGIC) and interacts with syntaxin 4 on phagosomes, mediates the recruitment of a subset of ER components, including transporter associated with antigen processing (TAP), to phagosomes.