Protein TAP2 map

Identifiers
HUGO:TAP2

References
PMID:16181333, PMID:22076556
Antigen peptides are transported into the ER from the cytosol via TAPs, tapasin stabilizes the TAP1/TAP2 heterodimer.
PMID:17204652
DCs, which are biased for MHCI cross-presentation, were enriched in Tap1, Tap2, calreticulin, calnexin, Sec61, ERp57, ERAAP, as well as cystatin B and C, all of which are involved in MHCI presentation or inhibition of enzymes that process peptides for MHCII presentation
PMID:11717192
The gene expression of TAP1, TAP2, tapasin, ??2m and HLA-?? HC is up-regulated in mature DC.
TAP-mediates peptide transport and loading on MHC class I in purified phagosomes.

Modifications:
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane
  1. TAP1:​TAP2:​TAPASIN*@Endoplasmic Reticulum_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. TAP1:​TAP2:​TAPASIN*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TAP1:​TAP2:​TAPASIN*@Endoplasmic Reticulum_Membrane map → map TAP1:​TAP2:​TAPASIN*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
As Catalyser:
  1. Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map → map Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map