Protein CFL1 map

Identifiers
HUGO:CFL1
cofilin 1
HUGO:CFL1, HGNC:1874, ENTREZ:1072, UNIPROT:P23528, GENECARDS:GC11M065622

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:11698448 PMID:11093160
PMID:21178402
Activation of LIMK by ROCK has been linked to the phosphoregulation of ADF/cofilin.52,54???56 ADF/cofilin has been shown to be one of the key regulators of actin severing, nucleation and capping within the protrusive machinery
PMID:15866889
Cofilin is required for the maintenance of a polarized cytoskeleton and thus for directional cell miogration.
 NATURAL_KILLER  map
PMID:11698448
LIMK1 is a serine/threonine kinase that phosphorylates and inactivates the actin-depolymerization factor cofilin, thereby regulating actin cytoskeletal reorganization.
LIMK1 phosphorylates CLF1 (cofilin) downstream of killer cell-activating receptors via RHOA/ROCK1 pathway.
Inhibition of the p160ROCK/LIMK1 pathway results in decreased actin polymerization at the effector/target interface.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CFL1@INNATE_IMMUNE_CELL_Cytosol map
  2. CFL1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CFL1@INNATE_IMMUNE_CELL_Cytosol map → map CFL1|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map