Protein LIMK1 map

Identifiers
HUGO:LMK1
HUGO:LIMK1
LIM domain kinase 1
HUGO:LIMK1, HGNC:6613, ENTREZ:3984, UNIPROT:P53667, GENECARDS:GC07P073497

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:9655398
PMID:11698448 PMID:10652353
PMID:21178402
Activation of LIMK by ROCK has been linked to the phosphoregulation of ADF/cofilin.52,54???56 ADF/cofilin has been shown to be one of the key regulators of actin severing, nucleation and capping within the protrusive machinery
 NATURAL_KILLER  map
PMID:11698448
LIMK1 is a serine/threonine kinase that phosphorylates and inactivates the actin-depolymerization factor cofilin, thereby regulating actin cytoskeletal reorganization.
FcR-initiated LIMK1 phosphorylation was absent in the NK clones that had been treated with p160ROCK kinase inhibitor.
Inhibition of the RhoA/p160ROCK/LIMK1 signaling pathway abrogates lipid raft polarization to the effector-target interface

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LIMK1@INNATE_IMMUNE_CELL_Cytosol map
  2. LIMK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LIMK1@INNATE_IMMUNE_CELL_Cytosol map → map LIMK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CFL1@INNATE_IMMUNE_CELL_Cytosol map → map CFL1|​pho@INNATE_IMMUNE_CELL_Cytosol map