Identifiers
galectin 1
HUGO:LGALS1 hgnc_id:HGNC:6561 HGNC:6561 ENTREZ:3956 UNIPROT:P09382
MODULE:FIBROBLAST_ACTIVATION_MARKERS
HUGO:LGALS1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:21385934
Gal-1 expression is positively associated with ??-SMA in the stroma of OSCC specimens. Gal-1 knockdown decreases activated CAF characteristics, resulting in a decrease in ??-SMA expression and extracellular matrix protein production. Notably, blocking Gal-1 expression significantly inhibits CAF-conditioned medium-induced tumor cell migration and invasion, possibly by reducing the production of monocyte chemotactic protein-1 (MCP-1/CCL2). MCP-1 induces the migration of OSCC cells by binding to the receptor CCR2; adding an MCP-1 antibody to CAF-conditioned medium that inhibits the interaction between MCP-1 and CCR2 abolishes migration. Finally, we found that Gal-1 knockdown in CAFs significantly reduces CAF-augmented tumor growth and metastasis in vivo.
collagen I, fibroblast activation protein (FAP), ??-SMA, and fibronectin (FN) mRNA expression is reduced in sh-Gal-1 CAFs compared with sh-Luc CAFs.
CASCADE:LGALS1
PMID:21191065
Cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway.
LGALS1 upregulates ID3 expression, then ID3 upregulates expression of IL10 in DC.