Complex DAP12*:MIR183
Complex composition:
- MIR183
- DAP12*
DAP12*:MIR183@INNATE_IMMUNE_CELL_Cytosol
Identifiers
NAME:DAP12*:MIR183
References
NATURAL_KILLER
CASCADE:TGFB
PMID:24586048
Suppression of NK cells is a result of TGF-?? induction of microRNA (miR)-183, which binds and represses DNAX activating protein 12 kDa (DAP12), a signal adaptor for lytic function in NK cells
and interupts DAP12 dependent signaling (at least via NKp44 and KIR2DS4 receptors) .
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- DAP12*:MIR183@INNATE_IMMUNE_CELL_Cytosol
Participates in reactions:
As Reactant or Product:- DAP12*:MIR183@INNATE_IMMUNE_CELL_Cytosol
→
degraded
- rDAP12*@INNATE_IMMUNE_CELL_Cytosol
+ arMIR183@INNATE_IMMUNE_CELL_Cytosol
→
DAP12*:MIR183@INNATE_IMMUNE_CELL_Cytosol
As Catalyser: