Protein CCL19 map

Identifiers
HUGO:CCL19

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
 DENDRITIC_CELL  map
CASCADE:CCR7
CASCADE:IFNAB
PMID:17035340
The secretion of HMGB1 is required for the migration of maturing dendritic cells.
myeloid DC, which rapidly secrete upon maturation induction their own HMGB1, remodel their actin-based cytoskeleton, up-regulate the CCR7 and the CXCR4 chemokine receptors, and acquire the ability to migrate in response to chemokine receptor ligands. The events are apparently causally related: DC challenged with LPS in the presence of HMGB1-specific antibodies fail to up-regulate the expression of the CCR7 and CXCR4 receptors and to rearrange actin-rich structures. Moreover, DC matured in the presence of anti-HMGB1 antibodies fail to migrate in response to the CCR7 ligand CCL19 and to the CXCR4 ligand CXCL12

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CCL19@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CCL19@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CCL19:​CCR7@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CCL19@default map + CCR7@INNATE_IMMUNE_CELL_Membrane map → map CCL19:​CCR7@INNATE_IMMUNE_CELL_Membrane map
  2. rCCL19@INNATE_IMMUNE_CELL_Cytosol map → map CCL19@INNATE_IMMUNE_CELL_Cytosol map
  3. CCL19@INNATE_IMMUNE_CELL_Cytosol map → map CCL19@default map
As Catalyser:
  1. JAK3@INNATE_IMMUNE_CELL_Cytosol map → map JAK3@INNATE_IMMUNE_CELL_Cytosol map