Protein RUNX1 map

Identifiers
HUGO:RUNX1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
 NATURAL_KILLER  map
PMID:15084276
Granzyme B, perforin and Runx1 are direct and positievly regulated targets of TBX21 (T-BET) in NK cells.
PMID:18003603
RUNX1 down-regulates IFNG expression in NK cells and upregulates expression of CD122 (IL-2/IL-15 common receptor beta subunit) via direct binding to its promoter in development.
NK cells in Runx dominant negative form Tg mice have immature surface phenotype.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RUNX1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rRUNX1@INNATE_IMMUNE_CELL_Cytosol map → map RUNX1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIL2RB@INNATE_IMMUNE_CELL_Cytosol map → map rIL2RB@INNATE_IMMUNE_CELL_Cytosol map
    2. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map