Protein MAP3K14 map

Identifiers
HUGO:MAP3K14

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:21277899 PMID:15536066
CASCADE:IL18
 DENDRITIC_CELL  map
PMID:10679398
IL-18 receptor system consists of a ligand-binding subunit, IL-1Rrp and a signal transducing subunit, AcPL, analogous to the IL-1 receptor system.
The activated IL-1R???AcP complex recruits the serine/threonine kinase IL-1-receptor-associated kinase (IRAK) via the adaptor protein, MyD88.
After IRAK is phosphorylated, it dissociates from the receptor complex and interacts with TNF-receptor-associated factor 6 (TRAF6), which then relays the signal via NF-??B-inducing kinase (NIK) to two I-??B kinases (IKK-1 and IKK-2) leading to NF-??B activation.
PMID:17237376, PMID:21807870
Alternative pathways involeved IKKa activation by MAP3K14 (NIK). This signaling is important for DC maturation and T-cell activation (). NIK signaling is required in DCs to deliver co-stimulatory signals to CD4+??T cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MAP3K14@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MAP3K14@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K14@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. IKK_alpha_*|​hm2@INNATE_IMMUNE_CELL_Cytosol map → map IKK_alpha_*|​pho|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map