Protein CXCR3
Identifiers
HUGO:CXCR3
References
NATURAL_KILLER
CASCADE:CXCR3
PMID:18922917
Significantly lower numbers of tumor-infiltrating NK cells were detected in CXCR3???/??? mice, and the capacity of adoptively transferred CXCR3???/??? NK cells to accumulate in the tumor was severely impaired.
Ectopic expression of CXCL10 by tumor cells increased the numbers of NK cells in the tumors and prolonged NK cell???dependent survival.
Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
- CXCR3@INNATE_IMMUNE_CELL_Membrane
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- CXCL10:CXCR3@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- CXCL10@default
+ CXCR3@INNATE_IMMUNE_CELL_Membrane
→
CXCL10:CXCR3@INNATE_IMMUNE_CELL_Membrane
- CXCL10:CXCR3@INNATE_IMMUNE_CELL_Membrane
→
RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
As Catalyser: