Identifiers
HUGO:CXCL10
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / TREG_MODULATORS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
PMID:18514095
CXCL10 and CXCL11 ligands fo CXCR3 receptor are expressed in fibroblasts after TNF stimulation, and CXCL9 after IFNG stimulation
PMID:22798340
3-CXCR3 ligands (such as CXCL9, 10, and 11), also reportedly contribute to Treg-cell infiltration
PMID:23567181
CAF-mediated recruitment of T lymphocytes is facilitated by secretion of chemokines and cytokines that promote the recruitment of tumor-promoting T cells, including CXCL9, CXCL10, and CXCL12 (SDF-1??)
PMID:18922917
Significantly lower numbers of tumor-infiltrating NK cells were detected in CXCR3???/??? mice, and the capacity of adoptively transferred CXCR3???/??? NK cells to accumulate in the tumor was severely impaired.
Ectopic expression of CXCL10 by tumor cells increased the numbers of NK cells in the tumors and prolonged NK cell???dependent survival.
References
in_re575( Innate Immunity ):
PMID:23508573
HMGB1 induces secretion of CCL2, CCL3 and CXCL10 (IP-10) via TLR4 pathway.
→ CXCL10@default
+ CXCR3@INNATE_IMMUNE_CELL_Membrane → CXCL10:CXCR3@INNATE_IMMUNE_CELL_Membrane
→ RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
→ CXCL10@INNATE_IMMUNE_CELL_Cytosol