Identifiers
transforming growth factor, beta 1
HUGO:TGFB1, HGNC:11766, ENTREZ:7040, UNIPROT:P01137, GENECARDS:GC19M041837
HUGO:TGFB1
HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:21900405
TGFB inhibits proliferation
TGFB overproduction causes fibrosis.
PMID:15548370
TGFB1 is a prominent EMT-inducing factor.
The induction of EMT by TGFB1 is associated with the activation of JNK, p38, Erk, PI3k???Akt, and RhoA.
Activation of the Erk pathway is required for TGFB1???induced EMT In Vitro
PMID:11133108
C. parvum infection stimulates both IL8, TGFB secretion by both the basal and apical side of caco-2 cells
PMID:19920116
LAP is known to bind to ITG heterodimers and activate TGFB.
LAP and TGFB were also prominently expressed at the basal surface of endometrial epithelia
PMID:19010789
In early stages of carcinogenesis, TGBF has an anti-oncogenic effects:
TGFB inhibits the growth of epithelial cells.
In later stage, sensitivity to these effects of TGFB is frequently lost and TGFB would favor the development of tumors progression and metastasis
PMID:22703233
TGFB1 participates in M2 activation.
PMID:7594497
TGFB1 upregulates IL10 expression in macrophages.
TGFB1 and IL10 dowregulate expression of TNF.
PMID:21278795
TGFB-induced IRAK3 (IRAK-M) expression in tumor-associated macrophages
and inhibit TLR-dependent signaling
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID:19109155
MDSC inhibit cytotoxicity, NKG2D expression, and IFN-gamma production of NK cells both in vitro and in vivo.
Membrane-bound TGF-beta1 on MDSC is responsible for MDSC-mediated suppression of NK cells.
→ TGFB1@INNATE_IMMUNE_CELL_Cytosol
→ TGFB*@INNATE_IMMUNE_CELL_Cytosol