Identifiers
HUGO:RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
HUGO:RAF1, HGNC:9829, ENTREZ:5894??, GENECARDS:GC03M012625, UNIPROT:P04049
HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049
HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_NON_CANONICAL
References
PMID:11532940
PMID:24027568 PMID:14764585
PMID:9069260
Inactive RAF1 is associated in the cytoplasm with YWHAB.
YWHAB binds to RAF1 via the Ser259 phosphorylation site.
This interaction stabilises the inactive conformation of RAF1, in which the RAS-binding Cysteine-rich doomain (CRD) is obscured.
RAF1 contains an additional RAS-binding domain (RBD).
NATURAL_KILLER
PMID:15516985, PMID:12566895
HRAS activates MEK/ERK pathway via RAF phosphorylation in NK cells.
Ras functions asan adapter that binds to Raf kinases.
Raf can activate both MEK1 and MEK2 (also called MKK1 and MKK2)
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway.
Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation.
PMID:19289794 PMID:19565474