Protein IL1R1 map

Identifiers
interleukin 1 receptor type 1
HUGO:IL1R1 hgnc_id:HGNC:5993 HGNC:5993 ENTREZ:3554 UNIPROT:P14778
HUGO:IL1R
interleukin 1 receptor type I
IL1R IL1RA
HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
CASCADE:IL1
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
 MDSC  map
IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88.
PMID:11274345

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map
  2. IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  2. trILB1@default map + IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map → map IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map