Identifiers
HUGO:CDC42
cell division cycle 42
HUGO:CDC42 hgnc_id:HGNC:1736 HGNC:1736 ENTREZ:998 UNIPROT:P60953
HUGO:CDC42, HGNC:1736, ENTREZ:998, UNIPROT:P60953, GENECARDS:GC01P022379
HUGO:CDC42 HGNC:1736 ENTREZ:998 UNIPROT:P60953
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / RCD_GENES
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:7761442 PMID:22821962
CASCADE:CAV
PMID:17517963
caveolin-deficient MEFs showed a notable decrease in basal Rho activity and a significant increase in Rac and Cdc42 activity
PMID:21178402
Rac1 and Cdc42 activate ARP2/3 complex;
Rac1 and Cdc42 activate Wiskott-Aldrich Syndrome family of proteins including WASP, N-WASP and WAVE1/2.
Cdc42 is also involved in Golgi apparatus and MTOC reorientation in wound-edge fibroblasts.
PMID:27248291
Cdc42 regulates Cdc42EP3 function in cancer-associated ???broblasts
Inhibiting Cdc42 function by transient expression of the dominant negative Cdc42-N17
protein resulted in a loss of ???lamentous Cdc42EP3 structures and reduced F-actin stress ???bers and ???lamentous
SEPT2
PMID:15882626
Cdc42 and MRCK Activate Nuclear Movement to Reorient the MTOC (The microtubule-organizing center )in fibroblasts
CDC42 is a member of the RAS superfamily of small GTPases and plays an essential role in control of cell polarity, actin cytoskeleton rearrangements, protein traffickinf and directed cell movements.
PMID:10934474
PMID:11248548
PMID:11340065
PMID:15003621
CDC42 and cell polarity:
PMID:15020669
CDC42 functions in vivo:
PMID:18719708
NATURAL_KILLER
PMID:17785506
TRIP10 (CIP4) functions downstream of Cdc42 to induce MTOC polarization to the IS and cytotoxicity.
PMID:16329184
VAV1 and VAV2 proteins can activate cdc42
PMID:15001467
CD16 signaling activates cdc24 in NK cells probably via vav proteins.
PMID:22126964
Cdc42 activation is downstream of PI3K pathway (probably via VAVs)
PMID:15169870
Cdc42 activation was restricted to the leading margin of the cell, whereas Rac1 was active throughout the phagocytic cup. During phagosome closure, activation of Rac1 and Rac2 increased uniformly and transiently in the actin-poor region of phagosomal membrane. These distinct roles for Cdc42, Rac1, and Rac2 in the component activities of phagocytosis indicate mechanisms by which their differential regulation coordinates rearrangements of actin and membranes.
PMID:9831565, PMID:19741094
Inactivation of Cdc42, either by expression of a dominant-negative mutant or by knockdown, greatly inhibits phagocytosis
PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.