Protein WASL
References
PMID:19741094, PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.
WASP was required for actin polymerization, whereas N-WASP was required for pseudopod protrusion.
Cdc42 Is Required for Activation and Tyrosine Phosphorylation of WASP/N-WASP
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- WASL@INNATE_IMMUNE_CELL_Cytosol
- WASL|pho|active@INNATE_IMMUNE_CELL_Cytosol
Participates in complexes:
Participates in reactions:
As Reactant or Product:- WASL@INNATE_IMMUNE_CELL_Cytosol
→
WASL|pho|active@INNATE_IMMUNE_CELL_Cytosol
- WASL|pho|active@INNATE_IMMUNE_CELL_Cytosol
→
EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane
As Catalyser: