Identifiers
Rho-associated, coiled-coil containing protein kinase 1
HUGO:ROCK1, HGNC:10251, ENTREZ:6093, UNIPROT:Q13464, GENECARDS:GC18M018529
HUGO:ROCK1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
EMT Senescence / SENESCENCE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:19349987 PMID:27785353 PMID:11698448 PMID:10652353
NATURAL_KILLER
MACROPHAGE
CASCADE:CR3
PMID:12778124
The kinase activity of ROCKs is moderately enhanced after Rho binding.
PMID:11698448
p160ROCK plays a fundamental role in the development of cellular cytotoxicity via LIMK1 phosphorylation. But it does not affect conjugate formation.
PMID:12194823
Rho-kinase and myosin-II control phagocytic cup formation during CR3, but not FcgammaR, phagocytosis.
inhibition of the Rho --> ROK --> myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcgammaR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis.