Protein SHARPIN map

Identifiers
SHANK associated RH domain interactor
HUGO:SHARPIN hgnc_id:HGNC:25321 HGNC:25321 ENTREZ:81858 UNIPROT:Q9H0F6
HUGO:SHARPIN

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:24699077
LUBAC, linear ubiquitin chain assembly complex comprises????SHANK-associated RH-domain interactor (SHARPIN), heme-oxidized IRP2 ubiquitin ligase 1 homolog (HOIL1/RBCK1) and the E3 HOIL-1???interacting protein (HOIP/RNF31)
???is recruited to the TNFR1 complex via binding to the autoubiquitinated c-IAP1 and c-IAP2 proteins to mediate the assembly of linear polyubiquitin chains on NF-??B essential modifier (NEMO/IKBKG) and RIPK1

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RBCK1:​RNF31:​SHARPIN@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
    As Catalyser:
    1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map