Identifiers
epidermal growth factor
HUGO:EGF hgnc_id:HGNC:3229 HGNC:3229 ENTREZ:1950 UNIPROT:P01133
"epidermal growth factor (beta-urogastrone)"
HUGO:EGF HGNC:3229 ENTREZ:1950 UNIPROT:P01133
HUGO:EGF
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_SIGNALING_PATHWAYS
Cancer Associated Fibroblasts / GROWTH_FACTORS_PRODUCTION
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / TUMOR_GROWTH
References
CASCADE:TGFB
PMID:15175028
Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C ?? signaling pathway
PMID:15003992
TGF-??-mediated myofibroblast differentiation and proliferation of the NRK fibroblasts are mutually exclusive responses to TGF-??. Differentiation into myofibroblasts appears to be the default pathway whereas proliferation becomes the dominant and sole response when both TGF-?? and EGF are present.
PMID:18423981
EGF stimulates invasion of iHDF fibroblasts in collagen 3D-culture conditions,
provbably via RAC activation.
EGF down-regulated Rho-GTP levels in fibroblasts, giving permissive signals for Rac1 activation, fibroblast polarization, and invasion.
PMID:19631971
Fibroblasts cultivated in cancer cell CM express different growth factors,
bFGF mRNA and IL-1?? mRNA was increased after 12 h, whereas mRNA for bFGF, HB-EGF, HGF, IGF-1, and IL-1?? was increased after 24 h.
EGF mRNA was not increased by the CM at any time point.
PMID:21098712;
TGFB induces EGF expression and secretion in fibroblasts
MACROPHAGE
PMID:8101258
In cell populations derived from primary breast carcinoma, epidermal growth factor (EGF) is secreted by cells with the characteristic morphological and immunophenotypic profile of activated macrophages
PMID:15958574, PMID:15466195
Macrophages express epidermal growth factor (EGF), which promotes the formation of elongated protrusions and cell invasion by carcinoma cells. Colony stimulating factor 1 (CSF-1) produced by carcinoma cells promotes the expression of EGF by macrophages. In addition, EGF promotes the expression of CSF-1 by carcinoma cells thereby generating a positive feedback loop. Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion.
PMID:20430953