Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / DANGER_SIGNAL_PATHWAYS
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
DENDRITIC_CELL
CASCADE:S1PR
PMID:18362204
Apoptotic cells may up-regulate SphK1 to produce and secrete S1P that serves as a "come-and-get-me" signal for scavenger cells
PMID:11919175
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.
Immature and mature DC express the mRNA
for different S1P receptors, such as endothelial differentiation gene (EDG)-1, EDG-3, EDG-5, and
EDG-6. In immature DC, S1P stimulated pertussis toxin-sensitive Ca2+ increase actin polymerization and chemotaxis. These responses were lost by DC matured with
lipopolysaccharide. In maturing DC, however, S1P inhibited the secretion of tumor necrosis
factor ?? and interleukin (IL)-12, whereas it enhanced secretion of IL-10. As a consequence,
mature DC exposed to S1P showed a reduced and increased capacity to generate allogeneic Th1
and Th2 responses, respectively. In summary, our study implicates that S1P might regulate the
trafficking of DC and ultimately favor Th2 lymphocyte-dominated immunity.
→ RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
→ Sphingosine 1-phosphate@TUMOR_CELL_AS_INDUCTOR
+ S1PR*@INNATE_IMMUNE_CELL_Membrane → S1PR*:Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane