Protein PVRL2 map

Identifiers
HUGO:PVRL2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map

References
 NATURAL_KILLER  map
CASCADE:LFA1
PMID:16730454, PMID:24343663, PMID:18657862
DNAX accessory molecule-1 (DNAM-1, CD226) isa cell surface molecule capable of enhancing cytolytic activity and cytokine production in NK cells. Its ligands represented by two members of the nectin family: the poliovirus receptor (PVR CD155) and nectin-2 (CD112). Both molecules can be highly expressed in tumor cell lines, including carcinomas, melanomas and neuroblastomas.
PMID:21383766
In acute myeloid leukaemia an inverse correlation between CD112 expression
on AML blasts and DNAM-1 expression on NK cells was described

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. PVRL2@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. DNAM1*@INNATE_IMMUNE_CELL_Membrane map → map DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map
      2. DNAM1*@INNATE_IMMUNE_CELL_Cytosol map → map DNAM1*@INNATE_IMMUNE_CELL_Membrane map