Identifiers
HUGO:TP53
tumor protein p53
HUGO:TP53, HGNC:11998, ENTREZ:7157, UNIPROT:P04637, GENECARDS:GC17M007565
HUGO:TP53, HGNC:11998, ENTREZ:7157, UNIPROT:Q9NP68
HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637
HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
Regulated Cell Death / PENTOSE_PHOSPHATE_PATHWAY
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
Survival / WNT_CANONICAL
Survival / WNT_NON_CANONICAL
References
PMID:21518799
p53 activates MIR200C
PMID:21483453
p53 activates microRNAs
PMID:21336307
p53 activates MIR34
PMID:17823410
PMID:6396087, PMID:21340684, PMID:20457558, PMID:20182602, PMID:20066118
NATURAL_KILLER
PMID:22754780, PMID:21764762
Wild-type p53, but not mutant p53 interacts with UDLPs promoters and induces UDLP2 and UDLP1 expression in tumor cells and increases tumor immunogenicity.
UDLPs activate NKG2D* signaling in NK cells.Induction of wtp53 expression in tumor cells leads to their enhanced recognition by primary NK cells in a NKG2D-dependent manner.
PMID:22102694
Activation of p53 by Nutlin3a resulted in upregulation of Mir34a/c expression and decreased ULBP2 expression in several tumor models (but not in the all models).
P53 is a nuclear P38 target.
PMID:20506250
PMID:10721693
PMID:19459846