Protein PDL2* map

Identifiers
HUGO:PDCD1LG2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
PMID:24076050 PMID:12538684
PMID:26201938
CAFs expressed the co-regulatory molecules, B7H1 (PDL1) and B7DC (PDL2), whereas NFs (normal fibroblasts) did not
 DENDRITIC_CELL  map
PDL1 and PDL2 are expressed in DCs.
blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-gamma and IL-10, while blockade of PD-L1 results in similar, more modest, effects. Blockade of both PD-L1 and PD-L2 showed an additive effect. Both whole mAb and Fab enhanced T cell activation, showing that PD-L1 and PD-L2 function to inhibit T cell activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDL2*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PDL2*@INNATE_IMMUNE_CELL_Cytosol map → map Immune_checkpoints_T_cells_Inhibitors@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: