Identifiers
C-X-C motif chemokine ligand 6
HUGO:CXCL6 hgnc_id:HGNC:10643 HGNC:10643 ENTREZ:6372 UNIPROT:P80162
HUGO:CXCL6
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
References
PMID:24406209
CXCL6, like CXCL8, is involved in the recruitment of neutrophils.
NEUTROPHIL
CASCADE:RECRUITMENT_OF_IMMUNE_CELLS
PMID:21236563
Another chemokine recently
shown to be important in the recruitment of neutrophils to melanoma
tumors is GCP-2 (CXCL6). Specific anti-CXCL6 monoclonal antibodies
not only reduced recruitment of neutrophils to tumor sites in
mice but also caused reduction in tumor growth