Identifiers
indoleamine 2,3-dioxygenase 1
HUGO:IDO1 hgnc_id:HGNC:6059 HGNC:6059 ENTREZ:3620 UNIPROT:P14902
HUGO:IDO1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Cancer Associated Fibroblasts / TREG_MODULATORS
References
PMID:22182446
Increased levels of PGE2 were found in cocultured supernatants from HCC-derived fibroblasts, and up-regulated expression of IDO and COX-2 were detected in these cells.
The expression of NKP30, NKG2D, granzyme B and perforin were partly restored by PGE2 inhibitor and IDO inhibitor and
the production of TNF-?? and IFN-?? were fully restored by them.
PMID:23891282
IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells
DENDRITIC_CELL
MACROPHAGE
CASCADE:IFNG
CASCADE:TLR2_4
CASCADE:TNF
PMID:15459668
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan.Cells expressing IDO can suppress T-cell responses and promote tolerance
IDO could be expressed by Macrophages and DCs.
he mouse and human IDO gene promoters contain multiple sequence elements that confer responsiveness to type I (IFN-/) and, more potently, type II (IFN-) interferon.
IDO-expressing host APCs (whatever their subtype) might contribute to a state of local immunosuppression in tumour-draining lymph nodes, and might help to induce systemic tolerance to tumour antigens as well.
PMID:8663541
IFNG induces IDO expression via STAT1 and IRF-1 in DC
PMID:11477543
TLR4 -induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma in macrophages.