Identifiers
HUGO:CD276
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Cancer Associated Fibroblasts / TREG_MODULATORS
References
http://www.fasebj.org/content/23/1_Supplement/894.7.short
FIZZ1 binds to B7-H3 on fibroblasts and activates myofibroblast differentiation
This FIZZ1-B7-H3 interaction was confirmed by co-immunoprecipitation and FRET assays. B7-H3 expression by fibroblasts was confirmed by immunostaining and real time PCR. Further studies indicated that FIZZ1 induced the phosphorylation of B7-H3. In contrast to wild type fibroblasts, B7-H3 deficient cells from knockout mice failed to undergo myofibroblast differentiation in response to FIZZ1 treatment.??
PMID:??19544488??
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction
https://link.springer.com/chapter/10.1007%2F978-4-431-99644-6_60
The cell line named H1C1 had abilities to differentiate into adipocytes, osteocytes, and chondrocytes; therefore, we termed H1C1 as the human mesenchymal stem cells. RT-PCR showed that H1C1 constantly expressed mRNA of costimulatory molecules B7-H1, B7-H2, and B7-H3, which are known as immunosuppressive molecules. When human PBMC were cocultured with H1C1, the population of Tregs was increased compared with monoculture of PBMC, and neutralization of B7-H3 suppressed this induction. These results suggest that the human oral mesenchymal stem cells such as H1C1 have the abilities to suppress immunoreactions by costimulatory molecules and increasing Tregs.
DENDRITIC_CELL
PMID:17615586, PMID:15294965
After contact to Treg, DC up-regulate the inhibitory B7-H3 molecule and display reduced numbers of MHC???peptide complexes, leading to impaired T cell stimulatory function.
B7-H3 plays a significant role in suppressing T cell activation by Treg-exposed DC.
→ Immune_checkpoints_T_cells_Inhibitors@INNATE_IMMUNE_CELL_Membrane