Protein EGLN1 map

Identifiers
HUGO:EGLN1
egl nine homolog 1 (C. elegans)
HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
CASCADE:TGFB
PMID:25732824
Proline hydroxylase (PHD), a member of the dioxygenase family, hydroxylated HIF-1A at prolines 402 and 564. This hydroxylation led to the binding of E3 ligase VHL and consequent ubiquitination and degradation of HIF-1A. The activity of PHD requires oxygen and alpha-KG,
TGFB signaling regulates PDH activity downstream of TGFB
synonym:PHD2
PMID:21765015
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. EGLN1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map degraded