Protein SLC7A11 map

Identifiers
solute carrier family 7 member 11
HUGO:SLC7A11 hgnc_id:HGNC:11059 HGNC:11059 ENTREZ:23657 UNIPROT:Q9UPY5

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

References
PMID:27048822
PMID:26653790
PMID:26794443
 MACROPHAGE  map
 MDSC  map
PMID:20414655, PMID:2880923, PMID:3115975, PMID:20028852
Macrophages import cystine through their x c ??? transporter, reduce it to cysteine and then export the cysteine through their ASC neutral amino acid transporter.
PMID:20028852
MDSCs express the cystine transporter but lack cystathionase and the ASC neutral amino acid transporter
Therefore, macrophages, DCs, and MDSCs can import cystine; however, unlike macrophages and DCs, MDSCs are unable to export cysteine.
MDSC sequester cystine and prevent T cells from obtaining cysteine which is important for Tcell activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SLC7A11@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. SLC3A2:​SLC7A11@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. SLC3A2@INNATE_IMMUNE_CELL_Cytosol map + SLC7A11@INNATE_IMMUNE_CELL_Cytosol map → map SLC3A2:​SLC7A11@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Cystine@default map → map Cystine@INNATE_IMMUNE_CELL_Cytosol map