Protein KITLG map

Identifiers
KIT ligand
HUGO:KITLG HGNC:6343 ENTREZ:4254 UNIPROT:P21583
HUGO:KITLG

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
 MAST_CELL  map
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization, histamine, which is an immunosuppressant,
mitogenic factors, such as platelet-derived
growth factor (PDGF), nerve GF (NGF), stem-cell factor
(SCF), and proteases, which disrupt the surrounding
matrix and facilitate metastases.
PMID:18524989
SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment
Mast cell infiltration and activation in tumors were mainly mediated by tumor-derived stem cell factor (SCF) and its receptor
c-Kit on mast cells. tumor-derived SCF recruits MCs
to the tumor environment and also activates them.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. KITLG@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. KITLG@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIT:​KITLG@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KITLG@default map + KIT@INNATE_IMMUNE_CELL_Membrane map → map KIT:​KITLG@INNATE_IMMUNE_CELL_Membrane map
  2. KIT:​KITLG@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  3. KITLG@INNATE_IMMUNE_CELL_Cytosol map → map KITLG@default map
As Catalyser: