Identifiers
HUGO:FASLG
References
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
CASCADE:2B4
CASCADE:IFNAB
CASCADE:IL18
CASCADE:LFA1
PMID:12967644
IFNA signaling via STAT1 up-regulates gene expression of cytolytic effectors Fas-L in NK cells.
PMID:9858524
Mature CD56(+) NK cells mediate TRAIL-dependent and FasL-dependent cytotoxicity of tumor cells.
PMID:8892629
IFN-gamma-inducing factor (IL18) up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
PMID:23510023, PMID:23170255
TRAIL, FASL and TNF provides Dendritic cell tumor killing activity.
PMID:11823516
Human immature dendritic cells express on their cell surface four different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis inducing ligand; while cancer cells express the corresponding death receptors. Disruptions of interactions between the four ligands expressed on DCs and corresponding death-signaling receptors expressed on cancer cells using specific Abs or R:Fc fusion proteins block the cytotoxic activity of DCs directed against cancer cells.
TRAIL, FASL and TNF provides Dendritic cell tumor killing activity.()??