Identifiers
HUGO:MYLK HUGO:MYLK2
myosin light chain kinase
HUGO:MYLK hgnc_id:HGNC:7590 HGNC:7590 ENTREZ:4638 UNIPROT:Q15746
myosin light chain kinase 2
HUGO:MYLK2 hgnc_id:HGNC:16243 HGNC:16243 ENTREZ:85366 UNIPROT:Q9H1R3
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
References
PMID:19349987 PMID:27241914
PMID:11350763
Stress fiber organization is regulated by MLCK and Rho-kinase in cultured human fibroblasts
PMID:10953004
ROCK not only inhibits myosin phosphatase but also phosphorylates MLC directly in the center of cells (fibroblasts). At the cell periphery, on the other hand, MLCK but not ROCK appears to be the kinase responsible for phosphorylating MLC. These results suggest that ROCK and MLCK play distinct roles in spatial regulation of MLC phosphorylation.
MACROPHAGE
PMID:25712372, PMID:12194823
MLCK and ROCK phosphorylares RLC
inhibition of the Rho ??? ROK ??? myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment.
MLCK caused a significant reduction of both myosin-IIA localization and particle uptake, while it did not affect actin or Arp2/3 complex recruitment, suggesting a role for MLCK and myosin-IIA in later steps of phagosome formation
PMID:10733514
ERK2 activated MLCK, resulting in phosphorylation of the MLCK substrate or of the myosin light chain itself.
And induces phagocytosis.